Zotsatira zoyipa za ma coil a udzudzu amagetsi pa mazira a mbewa

Indonesia ndi dziko lotentha, zomwe zimapangitsa kuti likhale malo abwino kwambiri oberekera udzudzu. Kuchuluka kwa udzudzu woberekana kwapangitsa kuti pakhale njira zothetsera vutoli, lomwe ndi kugwiritsa ntchito mankhwala othamangitsa udzudzu—mankhwala ophera tizilombo ndi mankhwala osiyanasiyana.
Ma coil a udzudzu ali ndi zosakaniza zosiyanasiyana zogwira ntchito, monga d-allethrin, trans-flufenicol, bioallethrin, dimethoate, pyrifluquinazone, d-phenetrin,cypermethrin,kapena isoprenepyrine, zonse zomwe ndi mankhwala a pyrethroid. Mankhwala a pyrethroid ndi mankhwala ophera tizilombo omwe amatha kuletsa tizilombo kuyenda mwa kuwononga mitsempha yawo. Ma coil a udzudzu amapezeka m'masitolo ngati ma spray, ma coil, emulsions, ndi mankhwala othamangitsa tizilombo zamagetsi.

Kugwiritsa ntchito mopitirira muyeso mankhwala ophera udzudzu ndi mankhwala ena ophera tizilombo popanda kudziwa bwino kungakhale koopsa. Zotsatirapo zoipazi zingakhudze anthu, chilengedwe, ndi udzudzu okha. Kafukufuku wakale wa Almahdi et al. (2014) ndi Rahayuningsih (2006) adawonetsa kuti mbewa zapakati zimakumana ndi mankhwala ophera udzudzu okhala ndi trans-fluorometholone zomwe zimapangitsa kuti mwana wosabadwayo akhale ndi vuto komanso kuti mwana abadwe ndi thupi lochepa. Izi zikusonyeza kuti mankhwala ophera udzudzu angakhale ndi zotsatirapo zoipa kwa amayi apakati, chifukwa akazi amakhala okhudzidwa kwambiri ndi mankhwala panthawi ya mimba.
Mbewa zitha kugwiritsidwa ntchito ngati nyama za m'ma laboratories mu maphunziro okhudza teratogenicity omwe cholinga chake ndi kupeza chidziwitso cha zolakwika zomwe zimachitika m'mwana wosabadwayo chifukwa chokumana ndi mankhwala othamangitsa udzudzu panthawi ya organogenesis. Ofufuza akufuna kuphunzira zambiri za zotsatira za teratogenic za mankhwala ena othamangitsa udzudzu omwe ali ndi permethrin yogwira ntchito pa kulemera, kutalika kwa thupi, ndi zolakwika za kapangidwe ka thupi m'makanda a mbewa (Mus musculus). Kupuma mankhwala ophera tizilombo kwa nthawi yayitali kungayambitse poizoni ndikuyambitsa matenda a magazi, biochemical, ndi cytokine, komanso kuwonongeka kwa minofu.

Cholinga cha kafukufukuyu chinali kudziwa momwe mankhwala ophera tizilombo toyambitsa matenda amagetsi amakhudzira ana a mbewa (Mus musculus). Mankhwala ophera tizilombo toyambitsa matenda omwe amagwiritsidwa ntchito anali ndi 0.566% (4.2 mg/mL) ya permethrin, yomwe inapumidwa ndi mbewa zapakati panthawi ya organogenesis (masiku 6-15 a mimba). Makoswe makumi atatu apakati anagawidwa mwachisawawa m'magulu asanu (ofanana asanu ndi limodzi m'gulu lililonse): gulu C (gulu lolamulira, palibe kukhudzana ndi mankhwala ophera tizilombo toyambitsa matenda amagetsi); gulu T1 (maola 4 a tsiku ndi tsiku kukhudzana ndi mankhwala ophera tizilombo amagetsi); gulu T2 (maola 6 a tsiku ndi tsiku kukhudzana ndi mankhwala ophera tizilombo amagetsi); gulu T3 (maola 8 a tsiku ndi tsiku kukhudzana ndi mankhwala ophera tizilombo amagetsi); ndi gulu T4 (maola 10 a tsiku ndi tsiku kukhudzana ndi mankhwala ophera tizilombo amagetsi). Kulemera kwa mwana wosabadwayo ndi kutalika kwa thupi lake zinayesedwa, ndipo kusanthula kwa ziwerengero kunachitika pogwiritsa ntchito kusanthula kwa kusiyana kwa njira imodzi (ANOVA) ndi mayeso oyerekeza angapo a Duncan. Mayeso a Kruskal-Wallis ndi Mann-Whitney adagwiritsidwa ntchito pofufuza kuchuluka kwa kubadwa kwamoyo (%), kubadwa kwa akufa (%), ndi zolakwika za mawonekedwe (%). Zotsatira zake sizinasonyeze zolakwika zilizonse za kapangidwe ka thupi, koma kutuluka magazi pakhungu pang'ono kunawonedwa. Kusiyana kwakukulu kunapezeka pa kulemera ndi kutalika kwa mwana wosabadwayo, kuchuluka kwa kubadwa kwa mwana amoyo (%), kubadwa kwa mwana wakufa (%), ndi kutuluka magazi (%) (p).<0.05). Chiwerengero chachikulu cha imfa ndi kutuluka magazi m'mimba mwa chiberekero chinapezeka pambuyo pa maola 10 tsiku lililonse akumwa udzudzu wamagetsi.