Kukhudzana ndi mankhwala ena ophera tizilombo, monga mankhwala othamangitsa udzudzu, kumakhudzana ndi zotsatirapo zoyipa pa thanzi, malinga ndi kusanthula kwa deta ya kafukufuku wa boma.
Pakati pa omwe adatenga nawo mbali mu National Health and Nutrition Examination Survey (NHANES), kuchuluka kwa anthu omwe amapezeka ndi mankhwala ophera tizilombo omwe amagwiritsidwa ntchito m'nyumba omwe amagwiritsidwa ntchito kwambiri kunagwirizanitsidwa ndi chiopsezo chowonjezeka katatu cha imfa kuchokera ku matenda a mtima (chiŵerengero cha zoopsa ndi 3.00, 95% CI 1.02–8.80) Dr. Wei Bao ndi anzake ochokera ku University of Iowa ku Iowa City adanenanso.
Anthu omwe ali m'malo opezeka mankhwala ophera tizilombo amenewa anali pachiwopsezo chachikulu cha imfa ndi 56% chifukwa cha zifukwa zonse poyerekeza ndi anthu omwe ali m'malo opezeka mankhwala ophera tizilombo amenewa (RR 1.56, 95% CI 1.08–2. 26).
Komabe, olembawo adawona kuti mankhwala ophera tizilombo a pyrethroid sanagwirizane ndi imfa za khansa (RR 0.91, 95% CI 0.31–2.72).
Ma model adasinthidwa malinga ndi mtundu/fuko, kugonana, zaka, BMI, creatinine, zakudya, moyo, ndi zinthu zokhudzana ndi chikhalidwe cha anthu.
Mankhwala ophera tizilombo otchedwa pyrethroid amavomerezedwa kuti agwiritsidwe ntchito ndi bungwe la US Environmental Protection Agency ndipo nthawi zambiri amagwiritsidwa ntchito pochotsa udzudzu, mankhwala ophera nsabwe kumutu, shampu ndi zopopera za ziweto, ndi zinthu zina zoletsa tizilombo m'nyumba ndi panja ndipo amaonedwa kuti ndi otetezeka.
"Ngakhale kuti mankhwala ophera tizilombo opitilira 1,000 apangidwa, pali mankhwala ophera tizilombo okwana khumi ndi awiri okha omwe amapezeka pamsika wa US, monga permethrin, cypermethrin, deltamethrin ndi cyfluthrin," gulu la Bao linafotokoza, ndikuwonjezera kuti kugwiritsa ntchito mankhwala ophera tizilombo "kwawonjezeka." "M'zaka zaposachedwapa, vutoli lakula kwambiri chifukwa cha kusiya pang'onopang'ono kugwiritsa ntchito organophosphates m'nyumba zokhala anthu."
Mu ndemanga yomwe ili m'munsimu, Stephen Stellman, Ph.D., MPH, ndi Jean Mager Stellman, Ph.D., wa ku Columbia University ku New York, akunena kuti mankhwala otchedwa pyrethroids “ndi mankhwala achiwiri ophera tizilombo omwe amagwiritsidwa ntchito kwambiri padziko lonse lapansi, omwe ndi zikwi za makilogalamu ndi makumi a madola mamiliyoni aku US.” Kugulitsa kwa US m'madola aku US.
Komanso, “mankhwala ophera tizilombo toyambitsa matenda otchedwa pyrethroid amapezeka paliponse ndipo kufalikira kwake n’kosapeweka,” akulemba motero Stelmans. Si vuto la ogwira ntchito m’minda yokha: “Kupopera udzudzu m’mlengalenga kuti uthetse kachilombo ka West Nile ndi matenda ena ofalitsidwa ndi tizilombo ku New York ndi kwina kumadalira kwambiri tizilombo toyambitsa matenda otchedwa pyrethroid.”
Kafukufukuyu adafufuza zotsatira za akuluakulu oposa 2,000 omwe adachita nawo kafukufuku wa pulojekiti ya NHANES ya 1999-2000 omwe adayesedwa thupi, adatenga zitsanzo za magazi, ndikuyankha mafunso a kafukufuku. Kupezeka kwa pyrethroid mu mkodzo kunayesedwa ndi kuchuluka kwa 3-phenoxybenzoic acid, metabolite ya pyrethroid, ndipo ophunzirawo adagawidwa m'magulu a tertiles omwe adapezeka.
Pa nthawi yofufuza yapakati pa zaka 14, anthu 246 anamwalira: 52 ndi khansa ndipo 41 ndi matenda a mtima.
Pa avareji, anthu akuda omwe si a ku Spain ankadwala kwambiri matenda a pyrethroids kuposa a ku Spain ndi azungu omwe si a ku Spain. Anthu omwe ali ndi ndalama zochepa, maphunziro ochepa, komanso zakudya zosakwanira analinso ndi matenda ambiri a pyrethroids.
Stellman ndi Stellman adawonetsa "theka la moyo" wa ma biomarker a pyrethroid, pafupifupi maola 5.7 okha.
"Kupezeka kwa milingo ya ma metabolites a pyrethroid omwe amachotsedwa mwachangu m'magulu akuluakulu, osiyanasiyana m'malo osiyanasiyana kumasonyeza kuti matendawa amachitika kwa nthawi yayitali ndipo kumapangitsanso kuti pakhale kofunika kuzindikira magwero enieni a chilengedwe," adatero.
Komabe, adanenanso kuti chifukwa ophunzira omwe adachita nawo kafukufukuyu anali achichepere (zaka 20 mpaka 59), n'zovuta kuyerekeza mokwanira kuchuluka kwa mgwirizano womwe ulipo ndi imfa za matenda a mtima.
Komabe, "chiŵerengero cha zoopsa kwambiri" chikufunika kafukufuku wowonjezereka pa mankhwala awa ndi zoopsa zomwe zingachitike pa thanzi la anthu, adatero Stellman ndi Stellman.
Cholepheretsa china cha kafukufukuyu, malinga ndi olembawo, ndikugwiritsa ntchito zitsanzo za mkodzo wakumunda poyesa ma metabolites a pyrethroid, zomwe sizingawonetse kusintha pakapita nthawi, zomwe zimapangitsa kuti pakhale kusasankhidwa bwino kwa mankhwala ophera tizilombo a pyrethroid.
Kristen Monaco ndi wolemba wamkulu wodziwa bwino nkhani za endocrinology, psychiatry ndi nephrology. Ali ku ofesi ya ku New York ndipo wakhala akugwira ntchito ku kampaniyo kuyambira mu 2015.
Kafukufukuyu adathandizidwa ndi National Institutes of Health (NIH) kudzera ku University of Iowa Environmental Health Research Center.
Nthawi yotumizira: Sep-26-2023