PermaNet Dual, ukonde watsopano wosakanizidwa wa deltamethrin-clofenac, ukuwonetsa mphamvu zolimbana ndi udzudzu wa Anopheles gambiae womwe umalimbana ndi pyrethroid kum'mwera kwa Benin.

M'mayesero ku Africa, makoka opangidwa ndiPYRETHROIDndiMalingaliro a kampani FIPRONILadawonetsa zotsatira zabwino za entomological ndi epidemiological.Izi zapangitsa kuti pakhale kufunikira kwa maphunziro atsopano a pa intaneti awa m'maiko omwe ali ndi malungo.PermaNet Dual ndi deltamethrin ndi clofenac mesh yatsopano yopangidwa ndi Vestergaard Sàrl kuti ipereke mphamvu zowonjezera pamapulogalamu oletsa malungo.Tidachita mayeso oyendetsa ndege kuti tiwone momwe PermaNet Dual amathandizira polimbana ndi udzudzu wa Anopheles gambiae wakuthengo ku Cove, Benin.PermaNet Dual idayambitsa kufa kwa udzudzu kochuluka ngati sikunatsukidwe kuyerekeza ndi maukonde okhala ndi pyrethroid okha ndi maukonde okhala ndi pyrethroid ndi PIPERONYL BUTOXIDE (77% ya PermaNet Dual, 23% ya PermaNet 2.0 ndi 23% ya PermaNet 3.0) 56% p <120 zaka pambuyo pa 20%. .kuchapa kokhazikika (75% kwa PermaNet Dual, 14% kwa PermaNet 2.0, 30% kwa PermaNet 3.0, p <0.001).Pogwiritsa ntchito malire osakhala otsika omwe amatanthauzidwa ndi World Health Organization, PermaNet Dual nayenso sanali wotsika kwambiri pa imfa yonyamulira ku pyrethroid-clofenazoline, yomwe inasonyeza ubwino wa thanzi la anthu (Interceptor G2) (79% vs 76).%, OR = 0.878, 95% CI 0.719-1.073), koma osati kuteteza magazi (35% vs. 26%, OR = 1.424, 95% CI 1.177-1.723).PermaNet Dual ndi njira yowonjezera ku mtundu wothandiza kwambiri waukondewu kuti uthandizire kuwongolera malungo omwe amafalitsidwa ndi udzudzu wosamva pyrethroid.
Masikito ophera tizilombo (ITNs) ndi njira yothandiza kwambiri komanso yogwiritsidwa ntchito kwambiri popewera malungo.Awonetsedwa mobwerezabwereza kuti achepetse matenda a malungo ndi imfa muzoyeserera ndi mapulogalamu ndipo apereka chithandizo chachikulu chaposachedwa kuti achepetse matenda a malungo.Komabe, kudalira kwawo gulu limodzi la mankhwala ophera tizilombo (pyrethroids) kumapangitsa kuti pakhale mphamvu yosankha, kulimbikitsa kufalikira kwa pyrethroid resistance m'matenda a malungo.Pakati pa 2010 ndi 2020, kukana kwa pyrethroid kunapezeka mu mtundu umodzi wa vector mu 88% ya mayiko omwe ali ndi malungo.Ngakhale kuti kafukufuku wasonyeza kuti makoka okhala ndi mankhwala ophera tizilombo amateteza malungo ngakhale kuti amalimbana ndi malungo, pali umboni wamphamvu wakuti udzudzu umene umagwidwa ndi udzudzu umene umathiridwa ndi pyrethroid wathandiza kuti munthu azitha kukhala ndi moyo komanso kuti azidya.Poganizira kufunika kwake pa kupewa ndi kuletsa malungo, kuchepetsanso mphamvu ya maukonde ophera tizilombo kungachititse kuti matenda ayambirenso kufa.
Pothana ndi chiwopsezochi, makoka okhala ndi mankhwala ophera tizirombo aŵiri, omwe amaphatikiza pyrethroid ndi mankhwala ena, apangidwa kuti abwezeretse mphamvu ya tizilombo toyambitsa malungo.Mtundu woyamba watsopano wa ITN umaphatikiza ma pyrethroids ndiPIPERONYL BUTOXIDE (PBO), synergist yomwe imapangitsa kuti pyrethroids ikhale yogwira mtima pochepetsa ma enzymes omwe amaphatikizidwa ndi pyrethroid resistance10.M'nyumba zoyesera ndi ma cRCT ma ITN okhala ndi ma pyrethroids ndi PBO awonetsa zabwino kwambiri za entomological poyerekeza ndi ma ITN okhala ndi pyrethroids okha komanso epidemiological efficacy.Kuyambira pamenepo alandila upangiri wokhazikika wa WHO woti agawidwe m'malo omwe ma vector amawonetsa kukana ma pyrethroids, zomwe zidapangitsa kuti achuluke kwambiri kugawidwa kwawo m'maiko omwe ali ndi vuto lazaka zaposachedwa18.Komabe, pyrethroid-PBO ITN ilibe malire.Makamaka, pali nkhawa za kulimba kwawo pambuyo pakugwiritsa ntchito nthawi yayitali kunyumba.Kafukufuku woyendetsa ndege ku West Africa akuwonetsanso kuti ma neti oteteza udzudzu a pyrethroid-PBO angapereke phindu lochepa m'madera omwe ali ndi mphamvu yowonjezera ya pyrethroid yomwe imayendetsedwa ndi njira zovuta komanso zingapo.Choncho, pofuna kuteteza tizilombo toyambitsa matenda, m'pofunika kugwiritsa ntchito mitundu yambiri ya maukonde okhala ndi mankhwala ophera tizilombo, makamaka okhala ndi mankhwala ena atsopano omwe ma vectors amamva.
Posachedwapa, maukonde okhala ndi mankhwala ophera tizilombo apezeka omwe amaphatikiza pyrethroids ndi fipronil, mankhwala ophera tizirombo a azole omwe amasokoneza ntchito ya mitochondrial.Chlorfonopyr ikuyimira njira yatsopano yoyendetsera tizilombo toyambitsa matenda omwe apanga njira zovuta zolimbana ndi tizilombo tomwe timakhalapo kale.The pyrethroid-chlorphenopyr ITN (Interceptor G2), yopangidwa ndi BASF, yawonetsa malungo osamva pyrethroid m'mayesero oyesa ku Benin, Burkina Faso, Côte ndi Tanzania.Kuwongolera kwa ma Vector kwayenda bwino ndipo tsopano World Health Organisation ndiyoyenera.Mayesero akuluakulu ndi mapulogalamu oyendetsa ndege oyendetsa ndege m'mayiko ena awonetsanso umboni wokhudzana ndi miliri.Makamaka, ma RCTs ku Benin ndi Tanzania adawonetsa kuti Interceptor G2 yachepetsa kudwala malungo kwa ana ndi 46% ndi 44% pazaka ziwiri, motsatana, poyerekeza ndi ITN pogwiritsa ntchito pyrethroids wokhazikika.Potengera zotsatirazi, bungwe la World Health Organisation posachedwapa lapereka chilimbikitso champhamvu chogwiritsa ntchito maukonde opangidwa ndi mankhwala ophera tizilombo a pyrethroid-chlorphenopyr osati maukonde okhala ndi pyrethroids okha m'malo omwe ma vector samva ku pyrethroids.Ukonde wokhala ndi mankhwala ophera tizilombo kuti tipewe malungo.Izi zadzetsa chiwonjezeko chachikulu pakufunika kwapadziko lonse lapansi komanso kuyitanitsa maukonde otetezedwa ndi pyrethroid omwe adayikidwa m'maiko omwe ali ndi vuto.Kupanga mitundu yowonjezereka ya maukonde apamwamba a pyrethroid ndi fipronil opangidwa ndi opanga angapo omwe ali ndi mphamvu zopanga zopanga zidzathandiza kupititsa patsogolo msika wa mabedi ophera tizilombo, kuonjezera mpikisano, ndikuthandizira kupeza mosavuta maukonde ophera tizilombo otsika mtengo.Maukonde ogona.Maukonde ophera tizilombo kuti athe kuwongolera bwino ma vector.