Kuwonekera kwa pyrethroids kungapangitse chiopsezo cha matenda a Parkinson chifukwa chogwirizana ndi majini kudzera mu chitetezo cha mthupi.
Pyrethroids amapezeka muzamalonda ambirimankhwala apakhomo.Ngakhale ndi neurotoxic kwa tizilombo, nthawi zambiri amawonedwa ngati otetezeka kuti anthu azitha kulumikizana ndi akuluakulu aboma.
Kusiyanasiyana kwa majini ndi kukhudzana ndi mankhwala ophera tizilombo kumawoneka kuti zimakhudza chiopsezo cha matenda a Parkinson.Kafukufuku watsopano akupeza kugwirizana pakati pa zinthu ziwirizi zomwe zingayambitse chiopsezo, kuwonetsa udindo wa chitetezo cha mthupi pakukula kwa matenda.
Zopezazo zikugwirizana ndi kalasi yamankhwala ophera tizilombootchedwa pyrethroids, omwe amapezeka muzinthu zambiri zamalonda zamalonda ndipo amagwiritsidwa ntchito kwambiri paulimi pamene mankhwala ena ophera tizilombo amathetsedwa.Ngakhale ma pyrethroids ndi neurotoxic kwa tizilombo, akuluakulu aboma amawawona ngati otetezeka kuti adziwike ndi anthu.
Kafukufukuyu ndi woyamba kugwirizanitsa kukhudzana ndi pyrethroid ku chiopsezo cha majini ku matenda a Parkinson ndi maphunziro otsatila, adatero wolemba wamkulu Malu Tansi, Ph.D., pulofesa wothandizira wa physiology ku Emory University School of Medicine.
Ma genetic omwe gulu adapeza ali m'chigawo chosalemba ma jini a MHC II (major histocompatibility complex class II), gulu la majini omwe amayang'anira chitetezo chamthupi.
"Sitinayembekezere kupeza ulalo winawake wa pyrethroids," adatero Tansey.“Zimadziwika kuti kukhudzana kwambiri ndi pyrethroids kungayambitse kufooka kwa chitetezo cha mthupi, ndipo mamolekyu omwe amagwira nawo amatha kupezeka m'maselo oteteza thupi ku matenda;Tsopano tikuyenera kumvetsetsa zambiri za momwe kuwonekera kwa nthawi yayitali kumakhudzira chitetezo chamthupi ndipo potero kumawonjezera ntchito yake. ”Kuopsa kwa matenda a Kinson. "
“Pali kale umboni wamphamvu wakuti kutupa muubongo kapena chitetezo chamthupi chogwira ntchito mopitirira muyeso chingathandize kuti matenda a Parkinson achuluke."Tikuganiza kuti zomwe zikuchitika pano ndikuti kuwonetseredwa kwa chilengedwe kungasinthe momwe chitetezo cha mthupi chimayendera mwa anthu ena, kulimbikitsa kutupa kosatha muubongo."
Pa kafukufukuyu, ofufuza a Emory motsogoleredwa ndi Tansey ndi Jeremy Boss, Ph.D., wapampando wa Dipatimenti ya Microbiology ndi Immunology, adagwirizana ndi Stuart Factor, Ph.D., mkulu wa Emory's Comprehensive Parkinson's Disease Center, ndi Beate Ritz.MD, University of California, San Francisco.Mogwirizana ndi akatswiri ofufuza zaumoyo ku UCLA, Ph.D.Wolemba woyamba wa nkhaniyi ndi George T. Kannarkat, MD.
Ofufuza a UCLA adagwiritsa ntchito nkhokwe yaku California yofotokoza zaka 30 zakugwiritsa ntchito mankhwala ophera tizilombo paulimi.Amatsimikiza kuwonetseredwa potengera mtunda (kuntchito kwa winawake ndi maadiresi akunyumba) koma samayesa kuchuluka kwa mankhwala ophera tizilombo m'thupi.Ma pyrethroids amaganiziridwa kuti amawonongeka mwachangu, makamaka akakhala ndi kuwala kwa dzuwa, ndi theka la moyo m'nthaka yamasiku mpaka masabata.
Mwa anthu 962 ochokera ku Central Valley ku California, mtundu wamba wa MHC II wophatikizidwa ndi kukhudzana ndi mankhwala ophera tizilombo a pyrethroid unawonjezera chiopsezo cha matenda a Parkinson.Mtundu wowopsa kwambiri wa jini (anthu omwe amanyamula ma alleles oopsa) adapezeka mu 21% ya odwala omwe ali ndi matenda a Parkinson ndi 16% ya zowongolera.
M'gululi, kukhudzana ndi jini kapena pyrethroid yokha sikunawonjezere kwambiri chiopsezo cha matenda a Parkinson, koma kuphatikiza kunatero.Poyerekeza ndi pafupifupi, anthu omwe anali pachiopsezo cha pyrethroids ndipo anali ndi chiopsezo chachikulu cha mtundu wa MHC II anali ndi chiopsezo chowonjezeka cha 2.48 chokhala ndi matenda a Parkinson kusiyana ndi omwe ali ndi chiopsezo chochepa kwambiri cha jini.chiopsezo.Kukhudzana ndi mitundu ina ya mankhwala ophera tizilombo, monga organophosphates kapena paraquat, sikuwonjezera chiopsezo mofananamo.
Maphunziro akuluakulu a majini, kuphatikizapo Factor ndi odwala ake, adagwirizanitsapo kusiyana kwa majini a MHC II ndi matenda a Parkinson.Chodabwitsa n'chakuti, kusintha kwa majini komweko kumakhudza chiopsezo cha matenda a Parkinson mosiyana ndi anthu a ku Caucasus / a ku Ulaya ndi anthu a ku China.Majini a MHC II amasiyana kwambiri pakati pa anthu;choncho, amagwira ntchito yofunika kwambiri posankha zoika ziwalo.
Kuyesera kwina kwawonetsa kuti kusiyanasiyana kwa majini okhudzana ndi matenda a Parkinson kumagwirizana ndi magwiridwe antchito a chitetezo chamthupi.Ofufuza adapeza kuti pakati pa odwala 81 a Parkinson ndi maulamuliro a ku Ulaya ochokera ku yunivesite ya Emory, maselo a chitetezo cha mthupi kuchokera kwa anthu omwe ali ndi chiopsezo chachikulu cha jini ya MHC II kuchokera ku kafukufuku wa California anasonyeza mamolekyu ambiri a MHC.
Mamolekyu a MHC amayambitsa njira ya "antigen presentation" ndipo ndi mphamvu yomwe imayendetsa maselo a T ndikugwira ntchito zonse za chitetezo cha mthupi.Kufotokozera kwa MHC II kumawonjezeka m'maselo osasunthika a odwala matenda a Parkinson komanso kuwongolera bwino, koma kuyankha kwakukulu ku zovuta za chitetezo cha mthupi kumawonedwa mu odwala a Parkinson omwe ali ndi chiopsezo chachikulu cha genotypes;
Olembawo adamaliza kuti: "Zomwe timapeza zikuwonetsa kuti ma biomarker am'manja, monga kutsegulira kwa MHC II, atha kukhala othandiza kwambiri kuposa mamolekyu osungunuka mu plasma ndi cerebrospinal fluid pozindikiritsa anthu omwe ali pachiwopsezo cha matenda kapena kulemba odwala kuti achite nawo mayeso amankhwala osokoneza bongo.""Mayeso."
Kafukufukuyu adathandizidwa ndi National Institute of Neurological Disorders and Stroke (R01NS072467, 1P50NS071669, F31NS081830), National Institute of Environmental Health Sciences (5P01ES016731), National Institute of General Medical Sciences (GM47310), ndi Sartain Foundation Lanier ndi Michael J. Foxpa Kingson Foundation for Disease Research.
Nthawi yotumiza: Jun-04-2024