Kusiyanasiyana kwa majini a chitetezo chamthupi kumawonjezera chiopsezo cha matenda a Parkinson chifukwa chokhudzidwa ndi mankhwala ophera tizilombo

Kukumana ndi tizilombo toyambitsa matenda a pyrethroids kungapangitse kuti munthu adwale matenda a Parkinson chifukwa cha kuyanjana ndi majini kudzera mu chitetezo chamthupi.
Ma pyrethroids amapezeka m'masitolo ambirimankhwala ophera tizilombo apakhomoNgakhale kuti ndi poizoni ku tizilombo, nthawi zambiri akuluakulu aboma amaona kuti ndi otetezeka kuti anthu azitha kukhudzana nawo.
Kusiyanasiyana kwa majini ndi kupezeka kwa mankhwala ophera tizilombo zikuoneka kuti zimakhudza chiopsezo cha matenda a Parkinson. Kafukufuku watsopano wapeza kulumikizana pakati pa zinthu ziwirizi zoopsa, zomwe zikuwonetsa momwe chitetezo cha mthupi chimagwirira ntchito pakukula kwa matenda.
Zomwe zapezekazi zikukhudzana ndi gulu lamankhwala ophera tizilombootchedwa pyrethroids, omwe amapezeka m'mankhwala ambiri ophera tizilombo apakhomo ndipo akugwiritsidwa ntchito kwambiri muulimi pamene mankhwala ena ophera tizilombo akuthetsedwa. Ngakhale kuti pyrethroids ndi poizoni ku tizilombo, akuluakulu aboma nthawi zambiri amaona kuti ndi otetezeka kuti anthu asawawononge.
Kafukufukuyu ndi woyamba kulumikiza kufalikira kwa matenda a pyrethroid ndi chiopsezo cha majini cha matenda a Parkinson ndipo akuyenera kufufuzidwanso, anatero wolemba wamkulu Malu Tansi, Ph.D., pulofesa wothandizira wa physiology ku Emory University School of Medicine.
Mtundu wa majini womwe gululi linapeza uli m'dera losalemba ma code a majini a MHC II (major histocompatibility complex class II), gulu la majini omwe amalamulira chitetezo cha mthupi.
“Sitinayembekezere kupeza ulalo weniweni wa pyrethroids,” anatero Tansey. “Zikudziwika kuti kukhudzana ndi pyrethroids mwachangu kungayambitse kusagwira bwino ntchito kwa chitetezo chamthupi, ndipo mamolekyu omwe amagwira ntchito amapezeka m'maselo a chitetezo chamthupi; Tsopano tikufunika kumvetsetsa zambiri za momwe kukhudzana ndi nthawi yayitali kumakhudzira chitetezo chamthupi motero kumawonjezera ntchito yake.” Chiwopsezo cha matenda a Kinson.”
"Pali umboni wamphamvu kale wakuti kutupa muubongo kapena chitetezo chamthupi chogwira ntchito mopitirira muyeso chingathandize kuti matenda a Parkinson apitirire. "Tikuganiza kuti zomwe zikuchitika apa ndikuti kukhudzana ndi chilengedwe kungasinthe momwe chitetezo chamthupi chimayankhira mwa anthu ena, zomwe zimayambitsa kutupa kosatha muubongo."
Pa kafukufukuyu, ofufuza a Emory otsogozedwa ndi Tansey ndi Jeremy Boss, Ph.D., wapampando wa Dipatimenti ya Microbiology ndi Immunology, adagwirizana ndi Stuart Factor, Ph.D., mkulu wa Emory's Comprehensive Parkinson's Disease Center, ndi Beate Ritz., MD, University of California, San Francisco. Mogwirizana ndi ofufuza zaumoyo wa anthu ku UCLA, Ph.D. Wolemba woyamba wa nkhaniyi ndi George T. Kannarkat, MD.
Ofufuza a ku UCLA adagwiritsa ntchito database ya malo ku California yomwe idalemba zaka 30 za kugwiritsa ntchito mankhwala ophera tizilombo muulimi. Adapeza momwe mankhwalawa amakhudzira kutengera mtunda (ntchito ya munthu ndi ma adilesi akunyumba) koma sanayese kuchuluka kwa mankhwala ophera tizilombo m'thupi. Akuti ma pyrethroids amawonongeka mwachangu, makamaka akamakumana ndi dzuwa, ndipo amakhala ndi theka la moyo m'nthaka kuyambira masiku mpaka milungu.
Pakati pa anthu 962 ochokera ku Central Valley ku California, mtundu wa MHC II wodziwika bwino pamodzi ndi mankhwala ophera tizilombo otchedwa pyrethroid pesticides omwe amapha anthu ambiri kuposa omwe ali ndi kachilomboka unawonjezera chiopsezo cha matenda a Parkinson. Mtundu woopsa kwambiri wa jini (anthu omwe ali ndi ma alleles awiri oopsa) unapezeka mwa 21% ya odwala omwe ali ndi matenda a Parkinson ndi 16% ya odwala omwe ali ndi matendawa.
Mu gulu ili, kukhudzana ndi jini kapena pyrethroid yokha sikunawonjezere chiopsezo cha matenda a Parkinson, koma kuphatikiza kumeneku kunawonjezera chiopsezo. Poyerekeza ndi avareji, anthu omwe adakumana ndi pyrethroid ndipo anali ndi chiopsezo chachikulu cha jini la MHC II anali ndi chiopsezo chachikulu cha 2.48 chotenga matenda a Parkinson kuposa omwe anali ndi chiopsezo chochepa komanso anali ndi chiopsezo chochepa cha jini. Kukhudzana ndi mitundu ina ya mankhwala ophera tizilombo, monga organophosphates kapena paraquat, sikuwonjezera chiopsezo mwanjira yomweyo.
Kafukufuku wamkulu wa majini, kuphatikizapo Factor ndi odwala ake, adagwirizanitsa kale kusiyana kwa majini a MHC II ndi matenda a Parkinson. Chodabwitsa n'chakuti, kusiyana komweko kwa majini kumakhudza chiopsezo cha matenda a Parkinson mosiyana mwa anthu a ku Caucasus/Europe ndi anthu aku China. Majini a MHC II amasiyana kwambiri pakati pa anthu; chifukwa chake, amachita gawo lofunika kwambiri pakusankha ziwalo zina.
Kufufuza kwina kwasonyeza kuti kusiyanasiyana kwa majini komwe kumakhudzana ndi matenda a Parkinson kumagwirizana ndi ntchito ya maselo a chitetezo chamthupi. Ofufuza adapeza kuti pakati pa odwala 81 a matenda a Parkinson ndi oyang'anira aku Europe ochokera ku Emory University, maselo a chitetezo chamthupi ochokera kwa anthu omwe ali ndi majini a MHC II omwe ali pachiwopsezo chachikulu kuchokera ku kafukufuku waku California adawonetsa mamolekyu ambiri a MHC.
Mamolekyu a MHC ndiwo maziko a njira ya "kuonekera kwa antigen" ndipo ndi mphamvu yoyendetsera maselo a T ndikukhudza chitetezo chamthupi chonse. Kuwonekera kwa MHC II kumawonjezeka m'maselo odekha a odwala matenda a Parkinson ndi owongolera athanzi, koma kuyankha kwakukulu ku zovuta za chitetezo chamthupi kumawonedwa mwa odwala matenda a Parkinson omwe ali ndi majini oopsa kwambiri;
Olembawo adamaliza kuti: "Deta yathu ikusonyeza kuti ma biomarker a ma cell, monga MHC II activation, angakhale othandiza kwambiri kuposa mamolekyu osungunuka mu plasma ndi cerebrospinal fluid pozindikira anthu omwe ali pachiwopsezo cha matenda kapena polemba odwala kuti achite nawo mayeso a mankhwala oletsa chitetezo chamthupi." "Mayeso."
Kafukufukuyu adathandizidwa ndi National Institute of Neurological Disorders and Stroke (R01NS072467, 1P50NS071669, F31NS081830), National Institute of Environmental Health Sciences (5P01ES016731), National Institute of General Medical Sciences (GM47310), Sartain Lanier Family Foundation, ndi Michael J. Foxpa Kingson Foundation for Disease Research.