Zotsatira zoyipa za Florfenicol

       Florfenicolndi kupanga monofluoro linachokera thiamphenicol, chilinganizo maselo ndi C12H14Cl2FNO4S, woyera kapena woyera crystalline ufa, odorless, pang'ono kwambiri sungunuka m'madzi ndi chloroform, sungunuka pang'ono mu glacial acetic acid, sungunuka mu Methanol, Mowa. Ndi mankhwala atsopano ophatikizika a chloramphenicol ogwiritsidwa ntchito ndi ziweto, omwe adapangidwa bwino kumapeto kwa zaka za m'ma 1980.

Anagulitsidwa koyamba ku Japan mu 1990. Mu 1993, dziko la Norway linavomereza mankhwala ochizira furuncle ya salmon. Mu 1995, France, United Kingdom, Austria, Mexico ndi Spain adavomereza mankhwalawa pochiza matenda a bakiteriya opuma. Amaloledwanso kugwiritsidwa ntchito ngati chowonjezera cha nkhumba ku Japan ndi Mexico pofuna kupewa ndi kuchiza matenda a bakiteriya mu nkhumba, ndipo China tsopano yavomereza mankhwalawa.

Ndi mankhwala ophera maantibayotiki, omwe amapanga mawonekedwe ochulukirapo a bacteriostatic poletsa ntchito ya peptidyltransferase, ndipo ali ndi antibacterial yotakata, kuphatikiza zosiyanasiyana.Gram-positivendi mabakiteriya oipa ndi mycoplasma. Mabakiteriya okhudzidwa ndi ng'ombe ndi nkhumba Haemophilus,Shigella kamwazi, Salmonella, Escherichia coli, Pneumococcus, Influenza Bacillus, Streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, Rickettsia, etc. Mankhwalawa amatha kufalikira m'maselo a bakiteriya kudzera mumadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzimadzi, makamaka amachita pa 50sbit bacterial subunit 7 transpeptidase, imalepheretsa kukula kwa peptidase, imalepheretsa mapangidwe a peptide, potero imalepheretsa kaphatikizidwe ka mapuloteni, kukwaniritsa cholinga cha Antibacterial. Mankhwalawa amatengedwa mwachangu ndi makonzedwe amkamwa, amafalitsidwa kwambiri, amakhala ndi theka la moyo wautali, kuchuluka kwa mankhwala osokoneza bongo, komanso nthawi yayitali yosamalira mankhwala amagazi.
M'zaka zaposachedwa, minda yambiri ya nkhumba yaing'ono ndi yapakatikati yagwiritsa ntchito florfenicol pochiza mosasamala kanthu za momwe nkhumba zilili, ndipo amagwiritsa ntchito florfenicol ngati mankhwala amatsenga. Ndipotu izi ndi zoopsa kwambiri. Zili ndi zotsatira zabwino zochizira matenda a nkhumba zomwe zimayambitsidwa ndi mabakiteriya a Gram-positive ndi zoipa ndi mycoplasma, makamaka pambuyo pa kuphatikizika kwa florfenicol ndi doxycycline, zotsatira zake zimawonjezeka, ndipo zimathandiza pochiza nkhumba za nkhumba za thoracic atrophic rhinitis chain. Cocci, etc. amakhala ndi machiritso abwino.
Komabe, chifukwa chake zimakhala zowopsa kugwiritsa ntchito florfenicol pafupipafupi ndichifukwa chakuti florfenicol imakhala ndi zotsatirapo zambiri, ndipo kugwiritsa ntchito nthawi yayitali kwa florfenicol kumavulaza kwambiri kuposa zabwino. Mwachitsanzo, mabwenzi a nkhumba sayenera kunyalanyaza mfundo zimenezi.

1. Ngati pali matenda obwera chifukwa cha ma virus monga pseudorabies swine fever yokhala ndi mphete ya buluu m'makutu a nkhumba, kugwiritsa ntchito florfenicol pochiza nthawi zambiri kumakhala kothandizana ndi matenda a virus, ndiye ngati matenda omwe ali pamwambawa ali ndi kachilomboka ndipo amayamba matenda ena a nkhumba, musagwiritse ntchito florfenicol pochiza, zidzakulitsa matendawa.
2. Florfenicol idzasokoneza dongosolo lathu la hematopoietic ndikuletsa kupanga maselo ofiira a magazi m'mafupa, makamaka ngati nkhumba zathu zoyamwitsa zili ndi chimfine kapena kutupa. Mtundu wa tsitsi la nkhumba siwowoneka bwino, wokazinga, komanso umasonyeza zizindikiro za kuchepa kwa magazi m'thupi, umapangitsanso nkhumba kuti isadye motalika, kupanga nkhumba yolimba.
3. Florfenicol ndi embryotoxic. Ngati florfenicol imagwiritsidwa ntchito nthawi zambiri pamiyendo ya nkhumba, ana a nkhumba amatha kulephera.
4. Kugwiritsa ntchito florfenicol nthawi yayitali kumayambitsa matenda am'mimba komanso kutsekula m'mimba kwa nkhumba.
5. Ndizosavuta kuyambitsa matenda achiwiri, monga dermatitis exudative yomwe imayambitsidwa ndi matenda a staphylococcus mu nkhumba kapena matenda achiwiri a fungal dermatitis.
Mwachidule, florfenicol sayenera kugwiritsidwa ntchito ngati mankhwala wamba. Tikamagwiritsa ntchito maantibayotiki ena osagwira bwino ntchito komanso mosakanikirana (kutulutsa kachilomboka), titha kugwiritsa ntchito florfenicol ndi doxycycline pambali. Acupuncture amagwiritsidwa ntchito pochiza matenda osachiritsika, ndipo sikuvomerezeka pazochitika zina.