β-Triketone Nitisinone Imapha Udzudzu Wosagonjetsedwa ndi Tizilombo Potengera Khungu | Tizilombo ndi Ma Vectors

   Mankhwala ophera tizilomboKukana kwa tizilombo toyambitsa matenda pakati pa tizilombo toyambitsa matenda tomwe timafalitsa matenda ofunika kwambiri pa ulimi, ziweto, komanso thanzi la anthu onse kumabweretsa chiopsezo chachikulu ku mapulogalamu owongolera tizilombo toyambitsa matenda padziko lonse lapansi. Kafukufuku wakale wasonyeza kuti tizilombo toyambitsa matenda tomwe timayamwa magazi timafa kwambiri tikamadya mankhwala oletsa 4-hydroxyphenylpyruvate dioxygenase (HPPD) omwe ali ndi magazi, omwe ndi enzyme yachiwiri mu kagayidwe ka tyrosine. Kafukufukuyu adafufuza momwe mankhwala oletsa β-triketone HPPD amathandizira polimbana ndi mitundu itatu yayikulu ya tizilombo toyambitsa matenda, kuphatikizapo udzudzu womwe umafalitsa matenda akale monga malungo, matenda obwerezabwereza monga dengue ndi Zika, ndi mavairasi omwe akubwera monga mavairasi a Oropuche ndi Usutu.

Kusiyana pakati pa njira zogwiritsira ntchito pakhungu, tarsal ndi vial, njira zogwiritsira ntchito, kuperekera mankhwala ophera tizilombo komanso nthawi yomwe ntchito yake ikuchitika.
Komabe, ngakhale kuti panali kusiyana kwa imfa pakati pa New Orleans ndi Muheza pa mlingo wapamwamba kwambiri, kuchuluka kwa mankhwala ena onse kunali kothandiza kwambiri ku New Orleans (komwe kumakhudzidwa ndi matendawa) kuposa ku Muheza (kosagonjetsedwa ndi matendawa) kwa maola 24.
Zotsatira zathu zikusonyeza kuti nitisinone imapha udzudzu woyamwa magazi kudzera mu kukhudzana ndi transtarsal, pomwe mesotrione, sulfotrione, ndi tepoxiton sizimatero. Njira yophera iyi siyimasiyanitsa mitundu ya udzudzu yomwe imakhudzidwa kwambiri kapena yomwe imalimbana kwambiri ndi mitundu ina ya mankhwala ophera tizilombo, kuphatikizapo pyrethroids, organochlorines, ndi mwina carbamates. Kuphatikiza apo, mphamvu ya nitisinone popha udzudzu kudzera mu kuyamwa kwa epidermal sikungokhala pa mitundu ya Anopheles yokha, monga momwe zasonyezedwera ndi mphamvu yake motsutsana ndi Strongyloides quinquefasciatus ndi Aedes aegypti. Deta yathu ikuthandizira kufunikira kwa kafukufuku wowonjezereka kuti iwonjezere kuyamwa kwa nitisinone, mwina kudzera mu kuwonjezera mankhwala a epidermal kuyamwa kapena kuwonjezera zinthu zina zowonjezera. Kudzera mu njira yake yatsopano yogwirira ntchito, nitisinone imagwiritsa ntchito njira yoyamwa magazi ya udzudzu wamkazi. Izi zimapangitsa kuti ikhale njira yabwino yopezera mankhwala otsala m'nyumba komanso maukonde ophera tizilombo okhalitsa, makamaka m'madera omwe njira zachikhalidwe zopewera udzudzu sizigwira ntchito chifukwa cha kukana kwa pyrethroid mwachangu.