β-Triketone Nitisinone Imapha Udzudzu Wosamva Tizilombo Kudzera Kumayamwitsa Khungu | Ma Parasites ndi Vectors

   Mankhwala ophera tizilombokukana pakati pa ma arthropods omwe amafalitsa matenda ofunikira pazaulimi, zoweta ndi thanzi la anthu ndizowopsa kwambiri pamapulogalamu apadziko lonse lapansi owongolera ma vector. Kafukufuku wam'mbuyomu awonetsa kuti ma vector oyamwa magazi amafa kwambiri akamamwa magazi okhala ndi zoletsa za 4-hydroxyphenylpyruvate dioxygenase (HPPD), puloteni yachiwiri mu metabolism ya tyrosine. Kafukufukuyu adawunikira mphamvu za β-triketone HPPD inhibitors motsutsana ndi mitundu itatu yolimbana ndi matenda a pyrethroid, kuphatikiza udzudzu womwe umafalitsa matenda am'mbiri monga malungo, matenda obwera mobwerezabwereza monga dengue ndi Zika, ndi ma virus omwe akungobwera kumene monga ma virus a Oropuche ndi Usutu.

Kusiyana pakati pa njira zogwiritsira ntchito apamutu, tarsal ndi vial, njira zogwiritsira ntchito, kutumiza mankhwala ophera tizilombo komanso nthawi yochitirapo kanthu.
Komabe, ngakhale kusiyana kwa imfa pakati pa New Orleans ndi Muheza pa mlingo wapamwamba kwambiri, zina zonse zinali zogwira mtima ku New Orleans (zowonongeka) kusiyana ndi ku Muheza (zosamva) kupitirira maola 24.
Zotsatira zathu zikuwonetsa kuti nitisinone amapha udzudzu woyamwa magazi kudzera pa transtarsal contact, pamene mesotrione, sulfotrione, ndi tepoxiton samatero. Njira yophayi simasankha pakati pa mitundu ya udzudzu yomwe imamva bwino kapena yolimbana kwambiri ndi magulu ena ophera tizirombo, kuphatikiza ma pyrethroids, organochlorines, komanso mwina carbamates. Kuphatikiza apo, mphamvu ya nitisinone popha udzudzu kudzera m'mayamwidwe a epidermal sikuti ndi mitundu ya Anopheles yokha, monga momwe ikuwonetsedwera ndi mphamvu yake motsutsana ndi Strongyloides quinquefasciatus ndi Aedes aegypti. Zomwe timapeza zimathandizira pakufunika kofufuza kopitilira muyeso kuti mayamwidwe a nitisinone akwaniritsidwe, mwina kudzera mukulimbikitsa mayamwidwe a epidermal kapena kuwonjezera ma adjuvants. Kupyolera mu kachitidwe kake katsopano, nitisinone imagwiritsa ntchito khalidwe loyamwa magazi la udzudzu wamkazi. Izi zimapangitsa kuti ikhale yodalirika yopangira zopopera zotsalira m'nyumba komanso maukonde ophera tizilombo kwanthawi yayitali, makamaka m'madera omwe njira zachikhalidwe zopewera udzudzu sizigwira ntchito chifukwa chakufulumira kwa pyrethroid resistance.