Mankhwala othandiza Chowona Zanyama Colistin Sulfate CAS 1264-72-8

Mafotokozedwe Akatundu

Iwo makamaka ali amphamvu antibacterial kwambiri gram alibe mabakiteriya, ndi tcheru mabakiteriya monga Pseudomonas aeruginosa, Escherichia coli, Enterobacteria, Klebsiella, Salmonella, Shigella, Pasteurella ndi Vibrio. Proteus, Brucella, Serratia ndi mabakiteriya onse a Gram-positive anali osamva mankhwalawa.Colistin Sulfatekwa wosakwiya tizilombo toyambitsa matenda, udindo waukulu mu nembanemba bakiteriya cell, pamene kukhudzana ndi tcheru mabakiteriya, kapangidwe ake mankhwala a amino ufulu (Yang) ndi mankwala ester wa phosphoric asidi muzu pa bakiteriya cell nembanemba (ndi electronegative), kuonjezera permeability wa nembanemba, kuchititsa selo zinthu zofunika monga amino zidulo, Piao nyimbo, pyrimidine, K + pamenepo.

Akupempha

Amagwiritsidwa ntchito kwambiri pochiza matenda a m'mimba omwe amayamba chifukwa cha Grame-negative bacilli (Escherichia coli, etc.). Zimagwiranso ntchito polimbana ndi Pseudomonas aeruginosa (sepsis, matenda a mkodzo, kuyaka kapena matenda owopsa).

Mawonekedwe

(1) Ili ndi mphamvu yolimbana ndi mabakiteriya a Gram negative. Makamaka, imakhala ndi cholepheretsa chachitukuko pa Escherichia coli, Salmonella, ndi Pseudomonas aeruginosa.

(2) Imakhala ndi bactericidal effect. Polepheretsa ntchito yosankhidwa bwino ya ma cell membranes, mabakiteriya amafa.

(3) Palibe zovuta zokhudzana ndi mankhwala osokoneza bongo. Palibe kukana kwa R-factor komwe kunapezeka.

(4) Imagwira ntchito mogwirizana ndi mankhwala oletsa mabakiteriya a gram positive. Mukaphatikizana ndi zinki bacitracin, flavomycin, sulfonamides, semi synthetic penicillin, gentamicin, etc., zotsatira zake zimakhala bwino.

(5) Palibe zotsalira. Pamene kutumikiridwa pakamwa, pafupifupi osati otengeka ndi matumbo, koma mu mnofu jekeseni, kusonkhanitsa magazi ndi mayamwidwe ndi zabwino, kotero palibe chifukwa chodandaula za zotsalira mu mankhwala nyama.

(6) Limbikitsani kukula kwa ziweto ndi nkhuku, komanso kupewa ndi kuletsa matenda opatsirana amtundu wa ziweto ndi nkhuku.